Solid phase extraction spe is an extractive technique by which compounds that are dissolved or suspended in a liquid mixture are separated from other compounds in the mixture according to their physical and chemical properties analytical laboratories use solid phase extraction to concentrate and purify samples for analysis. Beginners guide to spe solid phase extraction a powerful tool for improved sample preparation as an analytical scientist you are faced with many challenges when determining what tools you can best use to achieve the desired result. Solid phase extraction spe is a form of step wise chromatography designed to extract partition and or adsorb one or more components from a liquid phase sample onto a stationary phase sorbent or resin over the last 25 years spe has become the most powerful technique available for the rapid and selective sample preparation prior to analytical chromatography spe extends the lifetime of . Solid phase extraction spe consists of a liquid or gaseous test sample in contact with a solid phase whereby the analyte is selectively adsorbed on the surface of the solid phase the basic principle of spe is the partitioning of compounds between two phases of solid and liquid and there must be greater affinity for the solid phase than for . Solid phase extraction spe is a technique designed for rapid selective sample preparation and purification prior to chromatographic analysis using liquid chromatography principles to control selectivity spe provides the sample cleanup recovery and concentration necessary for accurate quantitative analysis
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