Consequently this linker was used to perform successfully the solid phase synthesis of four different classes of estradiol derivatives in acceptable yields and excellent purities this study was preliminary to the combinatorial synthesis of larger libraries of biologically relevant estradiol derivatives. The mechanism of this transformation on solid support has been studied using 13c nmr and ir spectroscopies this new solid phase synthesis has been applied to the preparation of several bioactive dhps and is designed to be amenable to the split and pool protocol for combinatorial library synthesis. Determination of the absolute amount of resin bound hydroxyl or carboxyl groups for the optimization of solid phase combinatorial and parallel organic synthesis. During the course of our studies on therapeutic agents for the treatment of breast cancer we became interested in the solid phase combinatorial synthesis of estradiol derivatives that contain a functionalized side chain at either position 16 or 7 both types of compounds have already demonstrated inhibitory activity toward both biosynthesis and action of estradiol
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